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Papers

A curated bibliography of the group's work on non-B DNA prediction, interpretable deep learning for genomics, and the biological consequences of flipon variation — each entry linked to the model, dataset and code version it describes.

All ADAR1 G-quadruplexes Z-DNA benchmarking deep learning flipons immunity transcription

Zα and Zβ Localize ADAR1 to Flipons That Modulate Innate Immunity, Alternative Splicing, and Nonsynonymous RNA Editing

Herbert A, Cherednichenko O, Lybrand TP, Egli M, Poptsova M

Z-DNA flipons ADAR1 immunity

Int J Mol Sci, 2025 doi:10.3390/ijms26062422 Publisher ↗

Host cell Z-RNAs activate ZBP1 during virus infections

Yin C, Fedorov A, Guo H, Crawford JC, Rousseau C, Zhong X, Williams RM, Gautam A, Koehler HS, Whisnant AW, Hennig T, Rozina A, Zhong Y, Lv S, Bergant V, Wang S, Dröge P, Miller S, Poptsova M, Rehwinkel J, Pichlmair A, Mocarski ES, Thomas PG, Dölken L, Zhang T, Herbert A, Balachandran S

Z-DNA immunity

Nature, 2025 doi:10.1038/s41586-025-09705-5 Publisher ↗

Z-RNA and the Flipside of the SARS Nsp13 Helicase: Is There a Role for Flipons in Coronavirus-Induced Pathology?

Herbert A, Poptsova M

Z-DNA flipons immunity

Front Immunol, 2022 doi:10.3389/fimmu.2022.912717 Publisher ↗

Mono a Mano: ZBP1's Love-Hate Relationship with the Kissing Virus

Herbert A, Fedorov A, Poptsova M

immunity

Int J Mol Sci, 2022 doi:10.3390/ijms23063079 Publisher ↗

ADAR1 masks the cancer immunotherapeutic promise of ZBP1-driven necroptosis

Zhang T, Yin C, Fedorov A, Qiao L, Bao H, Beknazarov N, Wang S, Gautam A, Williams RM, Crawford JC, Peri S, Studitsky V, Beg AA, Thomas PG, Walkley C, Xu Y, Poptsova M, Herbert A, Balachandran S

ADAR1 immunity

Nature, 2022 doi:10.1038/s41586-022-04753-7 Publisher ↗